Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be effective in endometrial cancer. Recently it has been shown that hormone-bindin...

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Detalles Bibliográficos
Autores principales: Holst, Frederik, Hoivik, Erling A., Gibson, William J., Taylor-Weiner, Amaro, Schumacher, Steven E., Asmann, Yan W., Grossmann, Patrick, Trovik, Jone, Necela, Brian M., Thompson, E. Aubrey, Meyerson, Matthew, Beroukhim, Rameen, Salvesen, Helga B., Cherniack, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861919/
https://www.ncbi.nlm.nih.gov/pubmed/27160768
http://dx.doi.org/10.1038/srep25521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861919/
https://www.ncbi.nlm.nih.gov/pubmed/27160768
http://dx.doi.org/10.1038/srep25521

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