Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions is under tension, wh...

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Detalles Bibliográficos
Autores principales: Kumar, Abhishek, Ouyang, Mingxing, Van den Dries, Koen, McGhee, Ewan James, Tanaka, Keiichiro, Anderson, Marie D., Groisman, Alexander, Goult, Benjamin T., Anderson, Kurt I., Schwartz, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862330/
https://www.ncbi.nlm.nih.gov/pubmed/27161398
http://dx.doi.org/10.1083/jcb.201510012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862330/
https://www.ncbi.nlm.nih.gov/pubmed/27161398
http://dx.doi.org/10.1083/jcb.201510012

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