PDL1 Regulation by p53 via miR-34

BACKGROUND: Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34. METHODS: p53 wild-type and p53-deficient cell lines (p53(–/...

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Detalles Bibliográficos
Autores principales: Cortez, Maria Angelica, Ivan, Cristina, Valdecanas, David, Wang, Xiaohong, Peltier, Heidi J., Ye, Yuping, Araujo, Luiz, Carbone, David P., Shilo, Konstantin, Giri, Dipak K, Kelnar, Kevin, Martin, Desiree, Komaki, Ritsuko, Gomez, Daniel R., Krishnan, Sunil, Calin, George A., Bader, Andreas G., Welsh, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862407/
https://www.ncbi.nlm.nih.gov/pubmed/26577528
http://dx.doi.org/10.1093/jnci/djv303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862407/
https://www.ncbi.nlm.nih.gov/pubmed/26577528
http://dx.doi.org/10.1093/jnci/djv303

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