Histopathological Defects in Intestine in Severe Spinal Muscular Atrophy Mice Are Improved by Systemic Antisense Oligonucleotide Treatment

Gastrointestinal (GI) defects, including gastroesophageal reflux, constipation and delayed gastric emptying, are common in patients with spinal muscular atrophy (SMA). Similar GI dysmotility has been identified in mouse models with survival of motor neuron (SMN) protein deficiency. We previously des...

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Detalles Bibliográficos
Autores principales: Sintusek, Palittiya, Catapano, Francesco, Angkathunkayul, Napat, Marrosu, Elena, Parson, Simon H., Morgan, Jennifer E., Muntoni, Francesco, Zhou, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862622/
https://www.ncbi.nlm.nih.gov/pubmed/27163330
http://dx.doi.org/10.1371/journal.pone.0155032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862622/
https://www.ncbi.nlm.nih.gov/pubmed/27163330
http://dx.doi.org/10.1371/journal.pone.0155032

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