Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2

Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die. Here, we show that mRNAs, but not noncoding RNAs, are rapidly and globally degraded during apoptosis. mRNA decay is triggered early...

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Detalles Bibliográficos
Autores principales: Thomas, Marshall P., Liu, Xing, Whangbo, Jennifer, McCrossan, Geoffrey, Sanborn, Keri B., Basar, Emre, Walch, Michael, Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862650/
https://www.ncbi.nlm.nih.gov/pubmed/25959823
http://dx.doi.org/10.1016/j.celrep.2015.04.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862650/
https://www.ncbi.nlm.nih.gov/pubmed/25959823
http://dx.doi.org/10.1016/j.celrep.2015.04.026

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