Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologi...

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Detalles Bibliográficos
Autores principales: Mavor, David, Barlow, Kyle, Thompson, Samuel, Barad, Benjamin A, Bonny, Alain R, Cario, Clinton L, Gaskins, Garrett, Liu, Zairan, Deming, Laura, Axen, Seth D, Caceres, Elena, Chen, Weilin, Cuesta, Adolfo, Gate, Rachel E, Green, Evan M, Hulce, Kaitlin R, Ji, Weiyue, Kenner, Lillian R, Mensa, Bruk, Morinishi, Leanna S, Moss, Steven M, Mravic, Marco, Muir, Ryan K, Niekamp, Stefan, Nnadi, Chimno I, Palovcak, Eugene, Poss, Erin M, Ross, Tyler D, Salcedo, Eugenia C, See, Stephanie K, Subramaniam, Meena, Wong, Allison W, Li, Jennifer, Thorn, Kurt S, Conchúir, Shane Ó, Roscoe, Benjamin P, Chow, Eric D, DeRisi, Joseph L, Kortemme, Tanja, Bolon, Daniel N, Fraser, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862753/
https://www.ncbi.nlm.nih.gov/pubmed/27111525
http://dx.doi.org/10.7554/eLife.15802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862753/
https://www.ncbi.nlm.nih.gov/pubmed/27111525
http://dx.doi.org/10.7554/eLife.15802

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