Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology

Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in Alzheimer's disease (AD). Integrative genomic analysi...

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Detalles Bibliográficos
Autores principales: Readhead, B, Haure-Mirande, J-V, Zhang, B, Haroutunian, V, Gandy, S, Schadt, E E, Dudley, J T, Ehrlich, M E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862938/
https://www.ncbi.nlm.nih.gov/pubmed/26552589
http://dx.doi.org/10.1038/mp.2015.167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862938/
https://www.ncbi.nlm.nih.gov/pubmed/26552589
http://dx.doi.org/10.1038/mp.2015.167

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