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LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation
B-cell receptor (BCR) signaling plays a critical role in B-cell activation and humoral immunity. In this study, we discovered a critical function of leucine-rich repeat kinase 1 (LRRK1) in BCR-mediated immune responses. Lrrk1(−/−) mice exhibited altered B1a-cell development and basal immunoglobulin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863158/ https://www.ncbi.nlm.nih.gov/pubmed/27166870 http://dx.doi.org/10.1038/srep25738 |