Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor

[Image: see text] Human cannabinoid type 1 (CB1) G-protein coupled receptor is a potential therapeutic target for obesity. The previously predicted and experimentally validated ensemble of ligand-free conformations of CB1 [Scott, C. E. et al. Protein Sci.2013, 22, 101−11323184890; Ahn, K. H. et al....

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Detalles Bibliográficos
Autores principales: Scott, Caitlin E., Ahn, Kwang H., Graf, Steven T., Goddard, William A., Kendall, Debra A., Abrol, Ravinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863456/
https://www.ncbi.nlm.nih.gov/pubmed/26633590
http://dx.doi.org/10.1021/acs.jcim.5b00581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863456/
https://www.ncbi.nlm.nih.gov/pubmed/26633590
http://dx.doi.org/10.1021/acs.jcim.5b00581

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