Photoreceptor Rescue by an Abbreviated Human RPGR Gene in a Murine Model of X-linked Retinitis Pigmentosa

The X-linked RP3 gene codes for the ciliary protein RPGR and accounts for over 10% of inherited retinal degenerations. The critical RPGR-ORF15 splice variant contains a highly repetitive purine-rich linker region that renders it unstable and difficult to adapt for gene therapy. To test the hypothesi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pawlyk, Basil S., Adamian, Michael, Sun, Xun, Bulgakov, Oleg V., Shu, Xinhua, Smith, Alexander J., Berson, Eliot L., Ali, Robin R., Khani, Shahrokh, F.Wright, Alan, Sandberg, Michael A., Li, Tiansen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863462/
https://www.ncbi.nlm.nih.gov/pubmed/26348595
http://dx.doi.org/10.1038/gt.2015.93

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863462/
https://www.ncbi.nlm.nih.gov/pubmed/26348595
http://dx.doi.org/10.1038/gt.2015.93

Ejemplares similares