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Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice

The present study investigated the effects of intrathecal administration of ProTx-II (tarantula venom peptide) and A803467 (5-[4-chloro-phenyl]-furan-2-carboxylic acid [3,5-dimethoxy-phenyl]-amide), selective Nav1.7 and Nav1.8 antagonists, respectively, on thermal hyperalgesia in a painful diabetic...

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Detalles Bibliográficos
Autores principales: Tanaka, Ken-ichiro, Sekino, Shota, Ikegami, Megumi, Ikeda, Hiroko, Kamei, Junzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863530/
https://www.ncbi.nlm.nih.gov/pubmed/27186141
http://dx.doi.org/10.2147/JEP.S79973