A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development

Although many preclinical programs in central nervous system research and development intend to develop highly selective and potent molecules directed at the primary target, they often act upon other off-target receptors. The simple rule of taking the ratios of affinities for the candidate drug at t...

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Detalles Bibliográficos
Autores principales: Spiros, Athan, Geerts, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863548/
https://www.ncbi.nlm.nih.gov/pubmed/27186116
http://dx.doi.org/10.2147/JEP.S30808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863548/
https://www.ncbi.nlm.nih.gov/pubmed/27186116
http://dx.doi.org/10.2147/JEP.S30808

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