Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells

Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin which glucosylates host GTPases to cause cytopathic and cytotoxic effects. TcsL has two enzymatic domains, an N-term...

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Detalles Bibliográficos
Autores principales: Craven, Ryan, Lacy, D. Borden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863631/
https://www.ncbi.nlm.nih.gov/pubmed/27303685
http://dx.doi.org/10.1128/mSphere.00012-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863631/
https://www.ncbi.nlm.nih.gov/pubmed/27303685
http://dx.doi.org/10.1128/mSphere.00012-15

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