Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generat...

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Detalles Bibliográficos
Autores principales: Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Israelsen, William J., Bhutkar, Arjun, Clish, Clary B., Davidson, Shawn M., Luengo, Alba, Bronson, Roderick T., Jacks, Tyler, Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734/
https://www.ncbi.nlm.nih.gov/pubmed/27125672
http://dx.doi.org/10.1101/gad.278549.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734/
https://www.ncbi.nlm.nih.gov/pubmed/27125672
http://dx.doi.org/10.1101/gad.278549.116

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