Cargando…

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Israelsen, William J., Bhutkar, Arjun, Clish, Clary B., Davidson, Shawn M., Luengo, Alba, Bronson, Roderick T., Jacks, Tyler, Vander Heiden, Matthew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734/ https://www.ncbi.nlm.nih.gov/pubmed/27125672 http://dx.doi.org/10.1101/gad.278549.116

Ejemplares similares

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
por: Dayton, Talya L., et al.
Publicado: (2018)

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis
por: Li, Carman Man-Chung, et al.
Publicado: (2015)

PKM2 is not required for colon cancer initiated by APC loss
por: Lau, Allison N., et al.
Publicado: (2017)

PKM2 is not required for pancreatic ductal adenocarcinoma
por: Hillis, Alissandra L, et al.
Publicado: (2018)

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer
por: Ng, Sheng Rong, et al.
Publicado: (2020)

p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
por: Brugarolas, James, et al.
Publicado: (1998)

Rapid modeling of cooperating genetic events in cancer through somatic genome editing
por: Sánchez-Rivera, Francisco J., et al.
Publicado: (2014)

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
por: Muzumdar, Mandar Deepak, et al.
Publicado: (2016)

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
por: Lau, Allison N, et al.
Publicado: (2020)

A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
por: Patel, Rupesh S., et al.
Publicado: (2022)

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
por: Luengo, Alba, et al.
Publicado: (2019)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
por: Luengo, Alba, et al.
Publicado: (2014)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1
por: Liu, Tong, et al.
Publicado: (2019)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis
por: Romero, Rodrigo, et al.
Publicado: (2017)

Suppression of Lung Adenocarcinoma Progression by Nkx2-1
por: Winslow, Monte M., et al.
Publicado: (2011)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K(ATP) channel
por: Foster, Hannah R, et al.
Publicado: (2022)

Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family
por: JnBaptiste, Courtney K., et al.
Publicado: (2017)

Metabolomics: an emerging but powerful tool for precision medicine
por: Clish, Clary B.
Publicado: (2015)

PKM and the maintenance of memory
por: Glanzman, David L.
Publicado: (2013)

Increased PHGDH expression promotes aberrant melanin accumulation
por: Mattaini, Katherine R., et al.
Publicado: (2019)

Survival of pancreatic cancer cells lacking KRAS function
por: Muzumdar, Mandar Deepak, et al.
Publicado: (2017)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
por: Bluemlein, Katharina, et al.
Publicado: (2011)

DDRE-07. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS
por: Ferraro, Gino, et al.
Publicado: (2021)

Structural basis of PKM2 regulation
por: Yang, Weiwei
Publicado: (2015)

PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

The Role of PKM2 in Diabetic Microangiopathy
por: Tu, Chao, et al.
Publicado: (2022)

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
por: Westcott, Peter M. K., et al.
Publicado: (2023)

Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
por: Akkari, Leila, et al.
Publicado: (2016)

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes
por: Soto-Feliciano, Yadira M., et al.
Publicado: (2017)

PKM2 functions as a histone kinase
por: Lu, Zhimin
Publicado: (2012)

Memory maintenance by PKMζ — an evolutionary perspective
por: Sacktor, Todd Charlton
Publicado: (2012)

PKM2 promotes reductive glutamine metabolism
por: Liu, Miao, et al.
Publicado: (2018)

Correction to: PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

Involvement of PKMζ in Stress Response and Depression
por: Liu, Jianfeng
Publicado: (2022)

Inducible de novo expression of neoantigens in tumor cells and mice with NINJA
por: Damo, Martina, et al.
Publicado: (2020)

Constraining ribosomal RNA conformational space
por: Favaretto, Paola, et al.
Publicado: (2005)

The Complex Effects of PKM2 and PKM2:IP(3)R Disruption on Intracellular Ca(2+) Handling and Cellular Functions
por: Lemos, Fernanda O., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n5fglq421as5gjbhth7hkk04gr