DNMT3A R882 Mutations Predict a Poor Prognosis in AML: A Meta-Analysis From 4474 Patients

DNA (cytosine-5)-methyltransferase 3 alpha (DNMT3A) mutations were widely believed to be independently associated with inferior prognosis in acute myeloid leukemia (AML) patients. As dominant missense alterations in DNMT3A mutations, R882 mutations cause the focal hypomethylation phenotype. However,...

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Detalles Bibliográficos
Autores principales: Yuan, Xiao-Qing, Peng, Li, Zeng, Wen-Jing, Jiang, Bin-Yuan, Li, Guan-Cheng, Chen, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
4800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863771/
https://www.ncbi.nlm.nih.gov/pubmed/27149454
http://dx.doi.org/10.1097/MD.0000000000003519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863771/
https://www.ncbi.nlm.nih.gov/pubmed/27149454
http://dx.doi.org/10.1097/MD.0000000000003519

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