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Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle

BACKGROUND: Cancer is considered the second leading cause of death in the world, and for the treatment of this disease, pharmacological intervention strategies are frequently based on chemotherapy. Doxorubicin (DOX) is one of the most widely used chemotherapeutic agents in clinical practice for trea...

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Detalles Bibliográficos
Autores principales: de Lima Junior, Edson Alves, Yamashita, Alex Shimura, Pimentel, Gustavo Duarte, De Sousa, Luís G. O., Santos, Ronaldo Vagner T, Gonçalves, Cinara Ludvig, Streck, Emilio Luiz, de Lira, Fábio Santos, Rosa Neto, Jose Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863825/
https://www.ncbi.nlm.nih.gov/pubmed/27239415
http://dx.doi.org/10.1002/jcsm.12104