Cargando…

Degenerin channel activation causes caspase‐mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle

BACKGROUND: Declines in skeletal muscle structure and function are found in various clinical populations, but the intramuscular proteolytic pathways that govern declines in these individuals remain relatively poorly understood. The nematode Caenorhabditis elegans has been developed into a model for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaffney, Christopher J., Shephard, Freya, Chu, Jeff, Baillie, David L., Rose, Ann, Constantin‐Teodosiu, Dumitru, Greenhaff, Paul L., Szewczyk, Nathaniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864282/ https://www.ncbi.nlm.nih.gov/pubmed/27493871 http://dx.doi.org/10.1002/jcsm.12040

Ejemplares similares

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans
por: Gaffney, Christopher J., et al.
Publicado: (2018)

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans
por: Etheridge, Timothy, et al.
Publicado: (2015)

The synaptic action of Degenerin/Epithelial sodium channels
por: Hill, Alexis S., et al.
Publicado: (2018)

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels
por: Kaulich, Eva, et al.
Publicado: (2022)

The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila
por: Zelle, Kathleen M., et al.
Publicado: (2013)

Integrated control of protein degradation in C. elegans muscle
por: Lehmann, Susann, et al.
Publicado: (2012)

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis
por: Crossland, Hannah, et al.
Publicado: (2021)

Identification and Functional Clustering of Genes Regulating Muscle Protein Degradation from amongst the Known C. elegans Muscle Mutants
por: Shephard, Freya, et al.
Publicado: (2011)

PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation
por: Chien, Hung-Che, et al.
Publicado: (2020)

PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
por: Chien, Hung-Che, et al.
Publicado: (2021)

The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes
por: Constantin-Teodosiu, Dumitru, et al.
Publicado: (2012)

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance
por: Handzlik, Michal K., et al.
Publicado: (2018)

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery
por: Varadhan, Krishna K., et al.
Publicado: (2018)

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end‐points
por: Crossland, Hannah, et al.
Publicado: (2018)

Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia?
por: Nemeth, Zoltan, et al.
Publicado: (2022)

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function
por: Atkins, Ryan, et al.
Publicado: (2021)

Expression of AmphiNaC, a new member of the amiloride-sensitive sodium channel related to degenerins and epithelial sodium channels in amphioxus
por: Candiani, Simona, et al.
Publicado: (2006)

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients
por: Casanova-Vallve, Nuria, et al.
Publicado: (2020)

Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia
por: Handzlik, Michal K., et al.
Publicado: (2021)

Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation
por: Lehmann, Susann, et al.
Publicado: (2012)

Effects of Endotoxaemia on Protein Metabolism in Rat Fast-Twitch Skeletal Muscle and Myocardium
por: Murton, Andrew J., et al.
Publicado: (2009)

Calpains Mediate Integrin Attachment Complex Maintenance of Adult Muscle in Caenorhabditis elegans
por: Etheridge, Timothy, et al.
Publicado: (2012)

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
por: Constantin-Teodosiu, Dumitru
Publicado: (2013)

Does carnitine supplementation truly increase whole‐body fat oxidation in older male adults during moderate‐intensity exercise?
por: Constantin‐Teodosiu, Dumitru
Publicado: (2021)

LTE: Does caffeine truly raise muscle carnitine in humans?
por: Constantin‐Teodosiu, Dumitru
Publicado: (2023)

Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD
por: Latimer, Lorna E., et al.
Publicado: (2022)

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression
por: Mallinson, Joanne E., et al.
Publicado: (2015)

Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans
por: Laranjeiro, Ricardo, et al.
Publicado: (2021)

Molecular Mechanisms of Muscle Fatigue
por: Constantin-Teodosiu, Dumitru, et al.
Publicado: (2021)

Methods to Assess Subcellular Compartments of Muscle in C. elegans
por: Gaffney, Christopher J., et al.
Publicado: (2014)

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization
por: Shur, Natalie F., et al.
Publicado: (2022)

Mitochondrial dysfunction causes Ca(2+) overload and ECM degradation–mediated muscle damage in C. elegans
por: Sudevan, Surabhi, et al.
Publicado: (2019)

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men
por: Gharahdaghi, Nima, et al.
Publicado: (2019)

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs
por: Hewitt, Jennifer E., et al.
Publicado: (2018)

Chemically defined medium and Caenorhabditis elegans
por: Szewczyk, Nathaniel J, et al.
Publicado: (2003)

Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways
por: Meesawatsom, Pongsatorn, et al.
Publicado: (2020)

Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks
por: Lessard, Sarah J., et al.
Publicado: (2013)

Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?
por: Morandi, Elena, et al.
Publicado: (2019)

Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy
por: Ellwood, Rebecca A., et al.
Publicado: (2021)

Genomic identification and functional analysis of essential genes in Caenorhabditis elegans
por: Yu, Shicheng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7cjthhtb749d2klbln8474gjnt