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Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells

The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were designed and synthesised for the detection of caspase-3 in live cells. A variety of modifications of...

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Detalles Bibliográficos
Autores principales: Pérez-López, Ana M., Soria-Gila, M. Lourdes, Marsden, Emma R., Lilienkampf, Annamaria, Bradley, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864350/
https://www.ncbi.nlm.nih.gov/pubmed/27168077
http://dx.doi.org/10.1371/journal.pone.0153209