Menadione Suppresses Benzo(α)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism

Oxidative reactions that are catalyzed by cytochromes P450 1A (CYP1A) lead to formation of carcinogenic derivatives of arylamines and polycyclic aromatic hydrocarbons (PAHs), such as the widespread environmental pollutant benzo(α)pyrene (BP). These compounds upregulate CYP1A at the transcriptional l...

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Detalles Bibliográficos
Autores principales: Sidorova, Yulia A., Perepechaeva, Maria L., Pivovarova, Elena N., Markel, Arkady L., Lyakhovich, Vyacheslav V., Grishanova, Alevtina Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864395/
https://www.ncbi.nlm.nih.gov/pubmed/27167070
http://dx.doi.org/10.1371/journal.pone.0155135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864395/
https://www.ncbi.nlm.nih.gov/pubmed/27167070
http://dx.doi.org/10.1371/journal.pone.0155135

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