Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4

Telomeres shorten with each cell division and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale genomic rearrangements of the kind frequently observed in human cancers. We have characterized more than 1400 telomere fusion events at the single-molecule leve...

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Detalles Bibliográficos
Autores principales: Liddiard, Kate, Ruis, Brian, Takasugi, Taylor, Harvey, Adam, Ashelford, Kevin E., Hendrickson, Eric A., Baird, Duncan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864465/
https://www.ncbi.nlm.nih.gov/pubmed/26941250
http://dx.doi.org/10.1101/gr.200840.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864465/
https://www.ncbi.nlm.nih.gov/pubmed/26941250
http://dx.doi.org/10.1101/gr.200840.115

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