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Immunocytochemical study of TOP2A and Ki-67 in cervical smears from women under routine gynecological care
BACKGROUND: Cervical cancer is one of the most common female cancers and is caused by human papillomavirus (HPV). Viral infection leads to cell cycle deregulation by inactivating p53 and retinoblastoma protein by viral oncoproteins E6 and E7, respectively. Then, nuclear proteins such as DNA topoisom...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864931/ https://www.ncbi.nlm.nih.gov/pubmed/27175798 http://dx.doi.org/10.1186/s12929-016-0258-z |