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Shared genetic contribution to ischemic stroke and Alzheimer's disease

OBJECTIVE: Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. METHODS: Using genome‐wide association study (GWAS) data from METASTROKE ...

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Autores principales: Traylor, Matthew, Adib‐Samii, Poneh, Harold, Denise, Dichgans, Martin, Williams, Julie, Lewis, Cathryn M., Markus, Hugh S., Fornage, Myriam, Holliday, Elizabeth G, Sharma, Pankaj, Bis, Joshua C, Psaty, Bruce M, Seshadri, Sudha, Nalls, Mike A, Devan, William J, Boncoraglio, Giorgio, Malik, Rainer, Mitchell, Braxton D, Kittner, Steven J, Ikram, M Arfan, Clarke, Robert, Rosand, Jonathan, Meschia, James F, Sudlow, Cathie, Rothwell, Peter M, Levi, Christopher, Bevan, Steve, Kilarski, Laura L, Walters, Matthew, Thijs, Vincent, Slowik, Agnieszka, Lindgren, Arne, de Bakker, Paul I W, Lambert, Jean‐Charles, Ibrahim‐Verbaas, Carla A, Naj, Adam C, Sims, Rebecca, Bellenguez, Céline, Jun, Gyungah, DeStefano, Anita L, Beecham, Gary W, Grenier‐Boley, Benjamin, Russo, Giancarlo, Thornton‐Wells, Tricia A, Jones, Nicola, Smith, Albert V, Chouraki, Vincent, Thomas, Charlene, Zelenika, Diana, Vardarajan, Badri N, Kamatani, Yoichiro, Lin, Chiao‐Feng, Gerrish, Amy, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie L, Ruiz, Agustin, Bihoreau, Marie‐Thçrèse, Choi, Seung‐Hoan, Reitz, Christiane, Pasquier, Florence, Hollingworth, Paul, Ramirez, Alfredo, Hanon, Olivier, Fitzpatrick, Annette L, Buxbaum, Joseph D, Campion, Dominique, Crane, Paul K, Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L, De Jager, Philip L, Deramecourt, Vincent, Johnston, Janet A, Evans, Denis, Lovestone, Simon, Letenneur, Luc, Morón, Francisco J, Rubinsztein, David C, Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M, Fiçvet, Nathalie, Huentelman, Matthew J, Gill, Michael, Brown, Kristelle, Kamboh, M Ilyas, Keller, Lina, Barberger‐Gateau, Pascale, McGuinness, Bernadette, Larson, Eric B, Green, Robert, Myers, Amanda J, Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Gallacher, John, St George‐Hyslop, Peter, Clarimon, Jordi, Lleo, Alberto, Bayer, Anthony, Tsuang, Debby W, Yu, Lei, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Proitsi, Petroula, Collinge, John, Sorbi, Sandro, Sanchez‐Garcia, Florentino, Fox, Nick C, Hardy, John, Deniz Naranjo, Maria Candida, Bosco, Paolo, Brayne, Carol, Galimberti, Daniela, Mancuso, Michelangelo, Matthews, Fiona, Moebus, Susanne, Mecocci, Patrizia, Del Zompo, Maria, Maier, Wolfgang, Hampel, Harald, Pilotto, Alberto, Bullido, Maria, Panza, Francesco, Caffarra, Paolo, Nacmias, Benedetta, Gilbert, John R, Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Pichler, Sabrina, Carrasquillo, Minerva M, Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G, Coto, Eliecer, Hamilton‐Nelson, Kara L, Gu, Wei, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael J, Faber, Kelley M, Jonsson, Palmi V, Combarros, Onofre, O'Donovan, Michael C, Cantwell, Laura B, Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H, Bennett, David A, Harris, Tamara B, Fratiglioni, Laura, Holmes, Clive, de Bruijn, Renee F A G, Passmore, Peter, Montine, Thomas J, Bettens, Karolien, Rotter, Jerome I, Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M, Kukull, Walter A, Hannequin, Didier, Powell, John F, Nalls, Michael A, Ritchie, Karen, Lunetta, Kathryn L, Kauwe, John S K, Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R, Schmidt, Reinhold, Rujescu, Dan, Wang, Li‐San, Dartigues, Jean‐François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M, Graff, Caroline, Jones, Lesley, Haines, Jonathan L, Holmans, Peter A, Lathrop, Mark, Pericak‐Vance, Margaret A, Launer, Lenore J, Farrer, Lindsay A, van Duijn, Cornelia M, Van Broeckhoven, Christine, Moskvina, Valentina, Schellenberg, Gerard D, Amouyel, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864940/
https://www.ncbi.nlm.nih.gov/pubmed/26913989
http://dx.doi.org/10.1002/ana.24621