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Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury

The calcineurin inhibitors cyclosporine A (CsA) and tacrolimus are widely used in the treatment of proteinuria diseases. As the direct target of these drugs, calcineurin has previously been demonstrated to play a role in proteinuria diseases. However, aside from its immune-related effects, the local...

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Detalles Bibliográficos
Autores principales: Ding, Fangrui, Li, Xuejuan, Li, Baihong, Guo, Jifan, Zhang, Yanqin, Ding, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865207/
https://www.ncbi.nlm.nih.gov/pubmed/27171192
http://dx.doi.org/10.1371/journal.pone.0155504