Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells

We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cancer cell lines, possibly via inducing oxidative stress...

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Detalles Bibliográficos
Autores principales: Huo, Haizhong, Zhou, Zhiyuan, Qin, Jian, Liu, Wenyong, Wang, Bing, Gu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865238/
https://www.ncbi.nlm.nih.gov/pubmed/27171435
http://dx.doi.org/10.1371/journal.pone.0154605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865238/
https://www.ncbi.nlm.nih.gov/pubmed/27171435
http://dx.doi.org/10.1371/journal.pone.0154605

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