Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells

Mitochondria that contain a mixture of mutant and wild-type mitochondrial (mt) DNA copies are heteroplasmic. In humans, homoplasmy is restored during early oogenesis and reprogramming of somatic cells, but the mechanism of mt-allele segregation remains unknown. In budding yeast, homoplasmy is restor...

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Detalles Bibliográficos
Autores principales: Ling, Feng, Niu, Rong, Hatakeyama, Hideyuki, Goto, Yu-ichi, Shibata, Takehiko, Yoshida, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865324/
https://www.ncbi.nlm.nih.gov/pubmed/27009201
http://dx.doi.org/10.1091/mbc.E15-10-0690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865324/
https://www.ncbi.nlm.nih.gov/pubmed/27009201
http://dx.doi.org/10.1091/mbc.E15-10-0690

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