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Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells
Mitochondria that contain a mixture of mutant and wild-type mitochondrial (mt) DNA copies are heteroplasmic. In humans, homoplasmy is restored during early oogenesis and reprogramming of somatic cells, but the mechanism of mt-allele segregation remains unknown. In budding yeast, homoplasmy is restor...
Autores principales: | Ling, Feng, Niu, Rong, Hatakeyama, Hideyuki, Goto, Yu-ichi, Shibata, Takehiko, Yoshida, Minoru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865324/ https://www.ncbi.nlm.nih.gov/pubmed/27009201 http://dx.doi.org/10.1091/mbc.E15-10-0690 |
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