Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability

KEY POINTS: The presynaptic protein α‐synuclein forms aggregates during Parkinson's disease. Accumulating evidence suggests that the small soluble oligomers of α‐synuclein are more toxic than the larger aggregates appearing later in the disease. The link between oligomer toxicity and structure...

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Detalles Bibliográficos
Autores principales: Kaufmann, Timothy J., Harrison, Paul M., Richardson, Magnus J. E., Pinheiro, Teresa J. T., Wall, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Neuroscience ‐ Neurobiology of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865569/
https://www.ncbi.nlm.nih.gov/pubmed/26915902
http://dx.doi.org/10.1113/JP271968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865569/
https://www.ncbi.nlm.nih.gov/pubmed/26915902
http://dx.doi.org/10.1113/JP271968

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