Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

Pulmonary fibrosis (PF) leads to progressive and often irreversible loss of lung functions, posing a health threat with no effective cure. We examined P-Rex1, a PI3K- and G protein βγ-regulated guanine nucleotide exchange factor (GEF) of the Rac small GTPase, for its potential involvement in PF. In...

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Detalles Bibliográficos
Autores principales: Liang, Qing, Cheng, Ni, Zhang, Gufang, Liang, Yurong, Qian, Feng, Wu, Dianqing, Ye, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865757/
https://www.ncbi.nlm.nih.gov/pubmed/27173636
http://dx.doi.org/10.1038/srep25785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865757/
https://www.ncbi.nlm.nih.gov/pubmed/27173636
http://dx.doi.org/10.1038/srep25785

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