Cargando…

Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex

Anticoagulant therapy is used for the prevention and treatment of thromboembolic disorders. Blood coagulation is initiated by the interaction of factor VIIa (FVIIa) with membrane-bound tissue factor (TF) to form the extrinsic tenase complex which activates FX to FXa. Thus, it is an important target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barnwal, Bhaskar, Jobichen, Chacko, Girish, Vallerinteavide Mavelli, Foo, Chun Shin, Sivaraman, J., Kini, R. Manjunatha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865804/ https://www.ncbi.nlm.nih.gov/pubmed/27173146 http://dx.doi.org/10.1038/srep25935

Ejemplares similares

Exactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus
por: Girish, Vallerinteavide Mavelli, et al.
Publicado: (2016)

Identification and Structural Characterization of a New Three-Finger Toxin Hemachatoxin from Hemachatus haemachatus Venom
por: Girish, Vallerinteavide Mavelli, et al.
Publicado: (2012)

A general approach to protein folding using thermostable exoshells
por: Sadeghi, Samira, et al.
Publicado: (2021)

Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System
por: Sadeghi, Samira, et al.
Publicado: (2022)

Nanoencapsulation as a General Solution for Lyophilization of Labile Substrates
por: Vallerinteavide Mavelli, Girish, et al.
Publicado: (2021)

Museum DNA reveals a new, potentially extinct species of rinkhals (Serpentes: Elapidae: Hemachatus) from the Eastern Highlands of Zimbabwe
por: Major, Tom, et al.
Publicado: (2023)

Thermostable exoshells fold and stabilize recombinant proteins
por: Deshpande, Siddharth, et al.
Publicado: (2017)

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa
por: Childers, Kenneth C., et al.
Publicado: (2022)

Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies
por: Foley, Jonathan H., et al.
Publicado: (2022)

Structural Basis for the Secretion of EvpC: A Key Type VI Secretion System Protein from Edwardsiella tarda
por: Jobichen, Chacko, et al.
Publicado: (2010)

Dimerization of VirD2 Binding Protein Is Essential for Agrobacterium Induced Tumor Formation in Plants
por: Padavannil, Abhilash, et al.
Publicado: (2014)

Scaffold stability and P14′ residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4
por: Walvekar, Varsha Ashok, et al.
Publicado: (2022)

Structure of GrlR and the Implication of Its EDED Motif in Mediating the Regulation of Type III Secretion System in EHEC
por: Jobichen, Chacko, et al.
Publicado: (2007)

Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
por: Jianwei, Li, et al.
Publicado: (2023)

Extrinsic stochastic factors (solute partition) in gene expression inside lipid vesicles and lipid-stabilized water-in-oil droplets: a review
por: Altamura, Emiliano, et al.
Publicado: (2018)

Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid
por: Sadeghi, Samira, et al.
Publicado: (2022)

SARS-CoV-2 Ion Channel ORF3a Enables TMEM16F-Dependent Phosphatidylserine Externalization to Augment Procoagulant Activity of the Tenase and Prothrombinase Complexes
por: Ludington, Jacob G, et al.
Publicado: (2021)

AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains
por: Singh, Ajit Kumar, et al.
Publicado: (2020)

Crystal Structure of Der f 7, a Dust Mite Allergen from Dermatophagoides farinae
por: Tan, Kang Wei, et al.
Publicado: (2012)

Extended Loop Region of Hcp1 is Critical for the Assembly and Function of Type VI Secretion System in Burkholderia pseudomallei
por: Lim, Yan Ting, et al.
Publicado: (2015)

Bacterioferritin nanocage structures uncover the biomineralization process in ferritins
por: Jobichen, Chacko, et al.
Publicado: (2023)

Toxinology provides multidirectional and multidimensional opportunities: A personal perspective
por: Kini, R. Manjunatha
Publicado: (2020)

High Thoracic Epidural Anesthesia and Dexmedetomidine for Awake Off-Pump Coronary Artery Bypass Grafting: A Feasible Option for Patients with Severe Pulmonary Disease
por: Barnwal, Neeraj K., et al.
Publicado: (2023)

Extrinsic geometric flows
por: Andrews, Ben, et al.
Publicado: (2020)

Extrinsic geometry of superimmersions
por: Curtright, T L
Publicado: (1988)

Role of extrinsic physical cues in cancer progression
por: Kim, Ok-Hyeon, et al.
Publicado: (2023)

Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury
por: Meves, Jessica M., et al.
Publicado: (2014)

Krait natriuretic peptide (KNP): a non-classical NP
por: Sridharan, Sindhuja, et al.
Publicado: (2013)

Snake venom natriuretic peptides: Potential molecular probes
por: Sridharan, Sindhuja, et al.
Publicado: (2015)

Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection
por: Gavor, Edem, et al.
Publicado: (2021)

Extrinsic geometry of convex surfaces
por: Pogorelov, A V, et al.
Publicado: (1973)

Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites
por: Kini, R. Manjunatha, et al.
Publicado: (2016)

Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms
por: Kini, R. Manjunatha, et al.
Publicado: (2023)

Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins
por: Gavor, Edem, et al.
Publicado: (2022)

Immune Checkpoint Inhibitors and the Exposome: Host-Extrinsic Factors Determine Response, Survival, and Toxicity
por: Pizzutilo, Elio Gregory, et al.
Publicado: (2023)

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
por: Putcha, Girish V., et al.
Publicado: (2002)

Free Radicals and Extrinsic Skin Aging
por: Poljšak, Borut, et al.
Publicado: (2012)

Extrinsic and intrinsic determinants of nerve regeneration
por: Ferguson, Toby A., et al.
Publicado: (2011)

Extrinsic regulation of satellite cell specification
por: Bentzinger, C Florian, et al.
Publicado: (2010)

PTX3 acts as an extrinsic oncosuppressor
por: Bonavita, Eduardo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c9vp3verjno44u90eonktrc3vi