Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

Dissecting the complexities of branched peptide-lipopolysaccharides (LPS) interactions provide rationale for the development of non-cytotoxic antibiotic adjuvants. Using various biophysical methods, we show that the branched peptide, B2088, binds to lipid A and disrupts the supramolecular organizati...

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Detalles Bibliográficos
Autores principales: Lakshminarayanan, Rajamani, Tan, Wei Xiang, Aung, Thet Tun, Goh, Eunice Tze Leng, Muruganantham, Nandhakumar, Li, Jianguo, Chang, Jamie Ya Ting, Dikshit, Neha, Saraswathi, Padmanabhan, Lim, Rayne Rui, Kang, Tse Siang, Balamuralidhar, Vanniarajan, Sukumaran, Bindu, Verma, Chandra S., Sivaraman, Jayaraman, Chaurasia, Shyam Sunder, Liu, Shouping, Beuerman, Roger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865820/
https://www.ncbi.nlm.nih.gov/pubmed/27174567
http://dx.doi.org/10.1038/srep25905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865820/
https://www.ncbi.nlm.nih.gov/pubmed/27174567
http://dx.doi.org/10.1038/srep25905

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