Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated with the full spectrum of fatty liver disease. To investigate the role of TM6SF2 in hepatic triglyceride (TG) metabolism, we inactivated the gene in mice. Chronic inac...

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Detalles Bibliográficos
Autores principales: Smagris, Eriks, Gilyard, Shenise, BasuRay, Soumik, Cohen, Jonathan C., Hobbs, Helen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865914/
https://www.ncbi.nlm.nih.gov/pubmed/27013658
http://dx.doi.org/10.1074/jbc.M116.719955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865914/
https://www.ncbi.nlm.nih.gov/pubmed/27013658
http://dx.doi.org/10.1074/jbc.M116.719955

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