PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition

BACKGROUND: Glioblastoma multiforme is the most aggressive malignant primary brain tumor, characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma. Both PI3K/Akt and JNK pathways are essential to glioblastoma cell survival, migration and invasion. Due to their...

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Detalles Bibliográficos
Autores principales: Zhao, Hua-Fu, Wang, Jing, Jiang, Hao-Ran, Chen, Zhong-Ping, To, Shing-Shun Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866398/
https://www.ncbi.nlm.nih.gov/pubmed/27176481
http://dx.doi.org/10.1186/s13046-016-0356-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866398/
https://www.ncbi.nlm.nih.gov/pubmed/27176481
http://dx.doi.org/10.1186/s13046-016-0356-5

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