CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

Cells require nucleotides to support DNA replication and to repair damaged DNA. In addition to de novo synthesis, cells recycle nucleotides from the DNA of dying cells or from cellular material ingested through the diet. Salvaged nucleosides come with the complication that they can contain epigeneti...

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Detalles Bibliográficos
Autores principales: Zauri, Melania, Berridge, Georgina, Thézénas, Marie-Laëtitia, Pugh, Kathryn M., Goldin, Robert, Kessler, Benedikt M., Kriaucionis, Skirmantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866471/
https://www.ncbi.nlm.nih.gov/pubmed/26200337
http://dx.doi.org/10.1038/nature14948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866471/
https://www.ncbi.nlm.nih.gov/pubmed/26200337
http://dx.doi.org/10.1038/nature14948

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