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Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models

Inverse statistical approaches to determine protein structure and function from Multiple Sequence Alignments (MSA) are emerging as powerful tools in computational biology. However the underlying assumptions of the relationship between the inferred effective Potts Hamiltonian and real protein structu...

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Detalles Bibliográficos
Autores principales: Jacquin, Hugo, Gilson, Amy, Shakhnovich, Eugene, Cocco, Simona, Monasson, Rémi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866778/
https://www.ncbi.nlm.nih.gov/pubmed/27177270
http://dx.doi.org/10.1371/journal.pcbi.1004889