The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

The DEAH-box NTPase Prp43 and its cofactors Ntr1 and Ntr2 form the NTR complex and are required for disassembling intron-lariat spliceosomes (ILS) and defective earlier spliceosomes. However, the Prp43 binding site in the spliceosome and its target(s) are unknown. We show that Prp43 fused to Ntr1�...

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Detalles Bibliográficos
Autores principales: Fourmann, Jean-Baptiste, Dybkov, Olexandr, Agafonov, Dmitry E, Tauchert, Marcel J, Urlaub, Henning, Ficner, Ralf, Fabrizio, Patrizia, Lührmann, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866824/
https://www.ncbi.nlm.nih.gov/pubmed/27115347
http://dx.doi.org/10.7554/eLife.15564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866824/
https://www.ncbi.nlm.nih.gov/pubmed/27115347
http://dx.doi.org/10.7554/eLife.15564

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