Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels

G protein gated inward rectifier K(+) (GIRK) channels open and thereby silence cellular electrical activity when inhibitory G protein coupled receptors (GPCRs) are stimulated. Here we describe an assay to measure neuronal GIRK2 activity as a function of membrane-anchored G protein concentration. Usi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Weiwei, Touhara, Kouki K, Weir, Keiko, Bean, Bruce P, MacKinnon, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866826/
https://www.ncbi.nlm.nih.gov/pubmed/27074662
http://dx.doi.org/10.7554/eLife.15751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866826/
https://www.ncbi.nlm.nih.gov/pubmed/27074662
http://dx.doi.org/10.7554/eLife.15751

Ejemplares similares