Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genomes. Due to their high levels of sequence identity and the existence of many polym...

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Detalles Bibliográficos
Autores principales: Philippe, Claude, Vargas-Landin, Dulce B, Doucet, Aurélien J, van Essen, Dominic, Vera-Otarola, Jorge, Kuciak, Monika, Corbin, Antoine, Nigumann, Pilvi, Cristofari, Gaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866827/
https://www.ncbi.nlm.nih.gov/pubmed/27016617
http://dx.doi.org/10.7554/eLife.13926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866827/
https://www.ncbi.nlm.nih.gov/pubmed/27016617
http://dx.doi.org/10.7554/eLife.13926

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