Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13

Tissue plasminogen activator (tPA) is an effective treatment for ischemic stroke, but its neurotoxicity is a significant problem. Here we tested the hypothesis that recombinant ADAMTS 13 (rADAMTS 13) would reduce tPA neurotoxicity in a mouse model of stroke. We show that treatment with rADAMTS 13 in...

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Detalles Bibliográficos
Autores principales: Fan, Mengchen, Xu, Haochen, Wang, Lixiang, Luo, Haiyu, Zhu, Ximin, Cai, Ping, Wei, Lixiang, Lu, Lu, Cao, Yongliang, Ye, Rong, Fan, Wenying, Zhao, Bing-Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867598/
https://www.ncbi.nlm.nih.gov/pubmed/27181025
http://dx.doi.org/10.1038/srep25971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867598/
https://www.ncbi.nlm.nih.gov/pubmed/27181025
http://dx.doi.org/10.1038/srep25971

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