BET and BRAF inhibitors act synergistically against BRAF‐mutant melanoma

Despite major advances in the treatment of metastatic melanoma, treatment failure is still inevitable in most cases. Manipulation of key epigenetic regulators, including inhibition of Bromodomain and extra‐terminal domain (BET) family members impairs cell proliferation in vitro and tumor growth in v...

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Detalles Bibliográficos
Autores principales: Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867668/
https://www.ncbi.nlm.nih.gov/pubmed/27169980
http://dx.doi.org/10.1002/cam4.667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867668/
https://www.ncbi.nlm.nih.gov/pubmed/27169980
http://dx.doi.org/10.1002/cam4.667

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