Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are e...

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Detalles Bibliográficos
Autores principales: Sharanek, Ahmad, Burban, Audrey, Burbank, Matthew, Le Guevel, Rémy, Li, Ruoya, Guillouzo, André, Guguen-Guillouzo, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867683/
https://www.ncbi.nlm.nih.gov/pubmed/27169750
http://dx.doi.org/10.1038/srep24709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867683/
https://www.ncbi.nlm.nih.gov/pubmed/27169750
http://dx.doi.org/10.1038/srep24709

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