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Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals

As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytopr...

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Detalles Bibliográficos
Autores principales: Gu, Shaobin, Wu, Ying, Yang, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867711/
https://www.ncbi.nlm.nih.gov/pubmed/27190706
http://dx.doi.org/10.7717/peerj.1983