Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

BACKGROUND: CRAd-S-pk7 is a conditionally replicative oncolytic adenoviral vector that contains a survivin promoter and a pk7 fiber modification that confer tumor-specific transcriptional targeting and preferential replication in glioma while sparing the surrounding normal brain parenchyma. METHODS:...

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Detalles Bibliográficos
Autores principales: Kim, Julius Woongki, Auffinger, Brenda, Spencer, Drew A., Miska, Jason, Chang, Alan L., Kane, Joshua Robert, Young, Jacob S., Kanojia, Deepak, Qiao, Jian, Mann, Jill F., Zhang, Lingjiao, Wu, Meijing, Ahmed, Atique U., Aboody, Karen S., Strong, Theresa V., Hébert, Charles D., Lesniak, Maciej S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868110/
https://www.ncbi.nlm.nih.gov/pubmed/27184224
http://dx.doi.org/10.1186/s12967-016-0895-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868110/
https://www.ncbi.nlm.nih.gov/pubmed/27184224
http://dx.doi.org/10.1186/s12967-016-0895-8

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