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N-Alpha-Acetyltransferases and Regulation of CFTR Expression

The majority of cystic fibrosis (CF)-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to the misfolding, mistrafficking, and degradation of the mutant protein. Inhibition of degradation does not effectively increase the amount of trafficking competent CFTR, bu...

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Detalles Bibliográficos
Autores principales: Vetter, Ali J., Karamyshev, Andrey L., Patrick, Anna E., Hudson, Henry, Thomas, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868295/
https://www.ncbi.nlm.nih.gov/pubmed/27182737
http://dx.doi.org/10.1371/journal.pone.0155430