SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A

In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A). Pap-A is a cyclic depsipeptide that binds to PS in the membrane of w...

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Detalles Bibliográficos
Autores principales: Cassilly, Chelsi D., Maddox, Marcus M., Cherian, Philip T., Bowling, John J., Hamann, Mark T., Lee, Richard E., Reynolds, Todd B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868317/
https://www.ncbi.nlm.nih.gov/pubmed/27183222
http://dx.doi.org/10.1371/journal.pone.0154932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868317/
https://www.ncbi.nlm.nih.gov/pubmed/27183222
http://dx.doi.org/10.1371/journal.pone.0154932

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