β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

Phosphodiesterase 10A (PDE10) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it appears to play an important role in cognition and psychomotor activity. PDE10 inhibitors are being developed for the treatment of schizophrenia and Huntington's diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Kevin, Lindsey, Ashley S., Li, Nan, Gary, Bernard, Andrews, Joel, Keeton, Adam B., Piazza, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868691/
https://www.ncbi.nlm.nih.gov/pubmed/26713600
http://dx.doi.org/10.18632/oncotarget.6705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868691/
https://www.ncbi.nlm.nih.gov/pubmed/26713600
http://dx.doi.org/10.18632/oncotarget.6705

Ejemplares similares