Cargando…

Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis

Angiogenesis is associated with the progression of multiple myeloma (MM). Wogonin is an active mono-flavonoid with remarkable antitumor activity. However, its impact on MM-stimulated angiogenesis remains largely unknown. Here, we demonstrated that wogonin decreased expression and secretion of pro-an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Rong, Chen, Yan, Wang, Xiao-Ping, An, Teng, Tao, Lei, Zhou, Yu-Xin, Huang, Yu-Jie, Chen, Bao-An, Li, Zhi-Yu, You, Qi-Dong, Guo, Qing-Long, Wu, Zhao-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868716/ https://www.ncbi.nlm.nih.gov/pubmed/26735336 http://dx.doi.org/10.18632/oncotarget.6796

Ejemplares similares

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
por: Schönenberger, Désirée, et al.
Publicado: (2016)

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma
por: Peng, Song, et al.
Publicado: (2020)

Playing Tag with HIF: The VHL Story
por: Leung, Sherri K., et al.
Publicado: (2002)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α
por: Fan, Yang, et al.
Publicado: (2016)

Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α
por: Wu, Shaojun, et al.
Publicado: (2021)

AB106. Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia
por: Zhai, Wei
Publicado: (2016)

Control of Angiogenesis via a VHL/miR-212/132 Axis
por: Lei, Zhiyong, et al.
Publicado: (2020)

VHL-HIF-2α axis-induced SEMA6A upregulation stabilized β-catenin to drive clear cell renal cell carcinoma progression
por: Ji, Jing, et al.
Publicado: (2023)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
por: Tarade, Daniel, et al.
Publicado: (2018)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
por: Tarade, Daniel, et al.
Publicado: (2019)

Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1α and survivin suppression
por: Khalmuratova, Roza, et al.
Publicado: (2018)

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway
por: Tang, Zhi, et al.
Publicado: (2021)

HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
por: Hughes, Michael D, et al.
Publicado: (2007)

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
por: Kondo, Keiichi, et al.
Publicado: (2003)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth
Publicado: (2003)

Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex
por: Sufan, Roxana I, et al.
Publicado: (2009)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
por: Park, Mi Hee, et al.
Publicado: (2014)

HIF2a inhibitors for the treatment of VHL disease
por: Metelo, Ana Martins, et al.
Publicado: (2015)

Human Papillomavirus 16 E6 Contributes HIF-1α Induced Warburg Effect by Attenuating the VHL-HIF-1α Interaction
por: Guo, Yi, et al.
Publicado: (2014)

Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia
por: Bi, Jianling, et al.
Publicado: (2017)

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis
por: Ma, Sai, et al.
Publicado: (2018)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system
por: Ni, Jieming, et al.
Publicado: (2021)

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
por: Schietke, Ruth E., et al.
Publicado: (2012)

Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
por: Kurihara, Toshihide, et al.
Publicado: (2011)

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
por: Li, Mingqing, et al.
Publicado: (2011)

HIF-2α-ILK Is Involved in Mesenchymal Stromal Cell Angiogenesis in Multiple Myeloma Under Hypoxic Conditions
por: Zhang, Xiaoying, et al.
Publicado: (2018)

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma
por: Sourbier, Carole, et al.
Publicado: (2012)

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
por: Frost, Julianty, et al.
Publicado: (2016)

Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes
por: Jiang, Xupin, et al.
Publicado: (2015)

The up‐regulation of NDRG1 by HIF counteracts the cancer‐promoting effect of HIF in VHL‐deficient clear cell renal cell carcinoma
por: Zhang, Zheng‐Yan, et al.
Publicado: (2020)

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma
por: Zhang, Shouhua, et al.
Publicado: (2023)

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide
por: Feng, Nan, et al.
Publicado: (2016)

VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells
por: Ma, Xueyou, et al.
Publicado: (2022)

Corrigendum: Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes
por: Jiang, Xupin, et al.
Publicado: (2015)

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish
por: Kim, Hyejeong Rosemary, et al.
Publicado: (2020)

Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth
por: Chen, Lixia, et al.
Publicado: (2016)

UBE2S promotes malignant properties via VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma
por: Wu, Junyi, et al.
Publicado: (2023)

Newcastle disease virus degrades HIF-1α through proteasomal pathways independent of VHL and p53
por: Abd-Aziz, Noraini, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_d8uvd2s008b1gskqtaho8qknvq