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RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis
Ribosomal protein S7 (RPS7) acts as a tumor suppressor in primary tumorigenesis but its role in cancer metabolism remains unclear. In this study, we demonstrate that RPS7 inhibits the colorectal cancer (CRC) cell glycolysis by suppressing the expression of hypoxia-inducible transcription factor-1α (...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868722/ https://www.ncbi.nlm.nih.gov/pubmed/26735579 http://dx.doi.org/10.18632/oncotarget.6807 |
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author | Zhang, Wen Tong, Duo Liu, Fei Li, Dawei Li, Jiajia Cheng, Xi Wang, Ziliang |
author_facet | Zhang, Wen Tong, Duo Liu, Fei Li, Dawei Li, Jiajia Cheng, Xi Wang, Ziliang |
author_sort | Zhang, Wen |
collection | PubMed |
description | Ribosomal protein S7 (RPS7) acts as a tumor suppressor in primary tumorigenesis but its role in cancer metabolism remains unclear. In this study, we demonstrate that RPS7 inhibits the colorectal cancer (CRC) cell glycolysis by suppressing the expression of hypoxia-inducible transcription factor-1α (HIF-1α) and the metabolic promoting proteins glucose transporter 4 (GLUT4) and lactate dehydrogenase B (LDHB). Further study found that the enhanced expression of HIF-1α abrogates the overexpression effects of RPS7 on CRC. In vivo assays also demonstrate that RPS7 suppresses colorectal cancer tumorigenesis and glycolysis. Clinically, the tissue microarray (TMA) analysis discloses the negative regulatory association between RPS7 and HIF-1α in colorectal cancer. Meanwhile, overexpression of RPS7 in colorectal cancer tissues predicts good overall survival and progression-free survival, but high expression level of HIF-1α indicates poor overall survival and progression-free survival. Overall, we reveal that RPS7 inhibits colorectal cancer glycolysis through HIF-1α-associated signaling and may be a promising biomarker for prognosis prediction and a potential target for therapeutic treatment. |
format | Online Article Text |
id | pubmed-4868722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48687222016-05-20 RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis Zhang, Wen Tong, Duo Liu, Fei Li, Dawei Li, Jiajia Cheng, Xi Wang, Ziliang Oncotarget Research Paper Ribosomal protein S7 (RPS7) acts as a tumor suppressor in primary tumorigenesis but its role in cancer metabolism remains unclear. In this study, we demonstrate that RPS7 inhibits the colorectal cancer (CRC) cell glycolysis by suppressing the expression of hypoxia-inducible transcription factor-1α (HIF-1α) and the metabolic promoting proteins glucose transporter 4 (GLUT4) and lactate dehydrogenase B (LDHB). Further study found that the enhanced expression of HIF-1α abrogates the overexpression effects of RPS7 on CRC. In vivo assays also demonstrate that RPS7 suppresses colorectal cancer tumorigenesis and glycolysis. Clinically, the tissue microarray (TMA) analysis discloses the negative regulatory association between RPS7 and HIF-1α in colorectal cancer. Meanwhile, overexpression of RPS7 in colorectal cancer tissues predicts good overall survival and progression-free survival, but high expression level of HIF-1α indicates poor overall survival and progression-free survival. Overall, we reveal that RPS7 inhibits colorectal cancer glycolysis through HIF-1α-associated signaling and may be a promising biomarker for prognosis prediction and a potential target for therapeutic treatment. Impact Journals LLC 2015-12-31 /pmc/articles/PMC4868722/ /pubmed/26735579 http://dx.doi.org/10.18632/oncotarget.6807 Text en Copyright: © 2016 Zhang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhang, Wen Tong, Duo Liu, Fei Li, Dawei Li, Jiajia Cheng, Xi Wang, Ziliang RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title | RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title_full | RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title_fullStr | RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title_full_unstemmed | RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title_short | RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis |
title_sort | rps7 inhibits colorectal cancer growth via decreasing hif-1α-mediated glycolysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868722/ https://www.ncbi.nlm.nih.gov/pubmed/26735579 http://dx.doi.org/10.18632/oncotarget.6807 |
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