Cargando…

Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair

Cardiac glycosides are clinically used for cardiac arrhythmias. In this study, we investigated the mechanism responsible for anti-cancer and radiosensitizing effects of lanatoside C in colorectal cancer cells. Lanatoside C-treated cells showed classic patterns of autophagy, which may have been cause...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Mi Ae, Kim, Mi-Sook, Kim, Wonwoo, Um, Jee-Hyun, Shin, Young-Joo, Song, Jie-Young, Jeong, Jae-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868741/ https://www.ncbi.nlm.nih.gov/pubmed/26756216 http://dx.doi.org/10.18632/oncotarget.6832

Ejemplares similares

Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction
por: Ha, Dat P., et al.
Publicado: (2021)

Lanatoside C Promotes Foam Cell Formation and Atherosclerosis
por: Shi, Huairui, et al.
Publicado: (2016)

The Effect of Lanatoside-C on the Response of the Human Cardiac Output to Walking Exercise
por: Goodyer, Allan V. N., et al.
Publicado: (1960)

Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma
por: Zhang, Chao, et al.
Publicado: (2023)

Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence
por: Kim, Hyun-Kyung, et al.
Publicado: (2018)

Combination of (131)I-trastuzumab and lanatoside C enhanced therapeutic efficacy in HER2 positive tumor model
por: Vinod, Nagarajan, et al.
Publicado: (2021)

Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery
por: Kim, Mi-Sook, et al.
Publicado: (2015)

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells
por: Kim, Moon-Hong, et al.
Publicado: (2015)

Suppression of Cpn10 Increases Mitochondrial Fission and Dysfunction in Neuroblastoma Cells
por: Park, So Jung, et al.
Publicado: (2014)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells
por: Chao, Min-Wu, et al.
Publicado: (2017)

Chromosome Damage in Relation to Recent Radiation Exposure and Radiation Quality in Nuclear Power Plant Workers
por: Kim, Yang Jee, et al.
Publicado: (2022)

β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species
por: KWAK, SEO-YOUNG, et al.
Publicado: (2014)

Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
por: Seo, Eunhui, et al.
Publicado: (2013)

Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
por: Lee, Shinrye, et al.
Publicado: (2021)

Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation
por: Kim, InYoung, et al.
Publicado: (2014)

Clinical Characteristics of Radiation Oncology in Korea during Past 10 Years
por: Ji, Young Hoon, et al.
Publicado: (2009)

Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-δ
por: Kim, Young-Ae, et al.
Publicado: (2013)

Deficiency in DNA damage response of enterocytes accelerates intestinal stem cell aging in Drosophila
por: Park, Joung-Sun, et al.
Publicado: (2018)

Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control
por: Sonn, Seong Keun, et al.
Publicado: (2022)

Repair of radiation damage to DNA
por: Willers, H, et al.
Publicado: (2004)

Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways
por: Reddy, Dhanasekhar, et al.
Publicado: (2019)

Trans-Differentiation of Neural Stem Cells: A Therapeutic Mechanism Against the Radiation Induced Brain Damage
por: Joo, Kyeung Min, et al.
Publicado: (2012)

Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage
por: Choi, Nuri, et al.
Publicado: (2021)

Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma
por: Zhang, Zhongkai, et al.
Publicado: (2020)

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
por: Cai, Shanshan, et al.
Publicado: (2023)

KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects
por: Kang, Kyoung Ah, et al.
Publicado: (2011)

Mitochondrial damage and radiation carcinogenesis
por: Hei, Tom K.
Publicado: (2014)

Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
por: Kim, Young Yeon, et al.
Publicado: (2017)

The complete mitochondrial genome information of Hynobius unisacculus (Amphibia, Caudata, Hynobiidae) and the phylogenetic implication
por: Suk, Ho Young, et al.
Publicado: (2019)

DNA damage repair is suppressed in porcine aged oocytes
por: Lin, Tao, et al.
Publicado: (2021)

The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
por: Lee, Seon-yeong, et al.
Publicado: (2018)

Risk of olfactory dysfunction of the workers in the automobile repair, printing, shoemaking and plating industries in Korea: a cross-sectional study
por: Lee, Soo-Jin, et al.
Publicado: (2018)

Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion
por: Jung, Chan-Hun, et al.
Publicado: (2019)

Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins
por: Jeong, Youn Kyoung, et al.
Publicado: (2015)

Effect of Chlorella intake on Cadmium metabolism in rats
por: Shim, Jee Ae, et al.
Publicado: (2009)

Voiding Dysfunction after Total Mesorectal Excision in Rectal Cancer
por: Kim, Jae Heon, et al.
Publicado: (2011)

DGG-100629 inhibits lung cancer growth by suppressing the NFATc1/DDIAS/STAT3 pathway
por: Im, Joo-Young, et al.
Publicado: (2021)

Effective and safe diet therapies for Lennox-Gastaut syndrome with mitochondrial dysfunction
por: Na, Ji-Hoon, et al.
Publicado: (2020)

Miconazole inhibits signal transducer and activator of transcription 3 signaling by preventing its interaction with DNA damage‐induced apoptosis suppressor
por: Yoon, Sung‐Hoon, et al.
Publicado: (2020)

Dysfunction of Mitochondrial Dynamics in Drosophila Model of Diabetic Nephropathy
por: Kim, Kiyoung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h5jo3dg96dmvns9m58qj4lfjgg