Cargando…
Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival
Clear cell renal cell carcinoma (ccRCC) is composed of cells whose cytoplasm filled with lipid droplets, subcellular organelles coated with adipocyte differentiation-related protein (ADFP) for the storage of triacylglycerol converted from excess free fatty acids. Mammalian cells primarily use the au...
Autores principales: | Xu, Guibin, Jiang, Yaodong, Xiao, Yuansong, Liu, Xian-De, Yue, Fei, Li, Wenjiao, Li, Xun, He, Yongzhong, Jiang, Xianhan, Huang, Hai, Chen, Qi, Jonasch, Eric, Liu, Leyuan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868754/ https://www.ncbi.nlm.nih.gov/pubmed/26701856 http://dx.doi.org/10.18632/oncotarget.6669 |
Ejemplares similares
-
Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis
por: Xu, Guibin, et al.
Publicado: (2016) -
Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation
por: Li, Wenjiao, et al.
Publicado: (2018) -
Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability
por: Zou, Jing, et al.
Publicado: (2013) -
Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin
por: Zou, Jing, et al.
Publicado: (2014) -
Mitochondrial E3 ubiquitin ligase 1 promotes autophagy flux to suppress the development of clear cell renal cell carcinomas
por: Yuan, Yaoji, et al.
Publicado: (2019)